Toll Like Receptor 1 (TLR1) Antibody Pair

Background

Toll-like receptor 1 (TLR1) is a member of the toll-like receptor (TLR) family, a critical component of the innate immune system that detects and responds to pathogens through pattern recognition. TLRs are integral to recognizing pathogen-associated molecular patterns (PAMPs), which are conserved molecular structures in microbes, such as bacterial cell wall components. TLR1, in particular, functions predominantly as a co-receptor with TLR2 and recognizes lipoproteins and lipopeptides derived from bacterial membranes. By binding these ligands, TLR1 initiates intracellular signaling pathways that activate pro-inflammatory cytokine production and immune cell recruitment, key processes for mounting an immune response against infection. TLR1 is primarily expressed on immune cells like monocytes, macrophages, dendritic cells, and neutrophils, and is involved in host defense against bacterial, fungal, and some viral pathogens. Its role in immune responses makes TLR1 a valuable focus for understanding immune signaling pathways and developing potential treatments for infections, inflammatory diseases, and cancers.