TNF Receptor Associated Factor 5 (TRAF5) Antibody
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Description
Polyclonal Antibody to TRAF5 (TRAF5).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | TNF Receptor Associated Factor 5 (TRAF5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00463 |
| Alias | TRAF-5,TRAF5, MGC:39780, RNF84, TNF receptor associated factor 5 |
| Background | Antibody anti-TRAF5 |
| Status | RUO |
Descripción
TRAF5 is a signaling adaptor protein that mediates pathways downstream of TNF receptors (TNFR), CD40, and BAFF-R, activating NF-κB and JNK to regulate inflammation, immune cell activation, and survival. TRAF5 plays a critical role in adaptive immune responses, particularly in T and B cell activation, cytokine production, and lymphoid tissue development. It works redundantly with TRAF2 to promote canonical NF-κB activation, ensuring appropriate immune responses to inflammatory and survival signals. TRAF5 is widely expressed in immune cells and epithelial tissues, where it supports cellular signaling during infections and tissue repair. Dysregulation of TRAF5 contributes to autoimmune diseases and inflammatory conditions, where altered NF-κB signaling enhances cytokine production and immune cell proliferation. Knockout studies reveal defects in lymphocyte activation, impaired cytokine signaling, and altered immune responses, highlighting its importance in immune regulation and inflammatory signaling.
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