Human TNF Receptor Associated Factor 5 (TRAF5) Protein

Este producto es parte de TRAF - TNF receptor associated factor
Human TNF Receptor Associated Factor 5 (TRAF5) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein TRAF5

proveedor

Abbexa

reference

abx069349

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant TRAF5 (TRAF5) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

TRAF5 is a signaling adaptor protein that mediates pathways downstream of TNF receptors (TNFR), CD40, and BAFF-R, activating NF-κB and JNK to regulate inflammation, immune cell activation, and survival. TRAF5 plays a critical role in adaptive immune responses, particularly in T and B cell activation, cytokine production, and lymphoid tissue development. It works redundantly with TRAF2 to promote canonical NF-κB activation, ensuring appropriate immune responses to inflammatory and survival signals. TRAF5 is widely expressed in immune cells and epithelial tissues, where it supports cellular signaling during infections and tissue repair. Dysregulation of TRAF5 contributes to autoimmune diseases and inflammatory conditions, where altered NF-κB signaling enhances cytokine production and immune cell proliferation. Knockout studies reveal defects in lymphocyte activation, impaired cytokine signaling, and altered immune responses, highlighting its importance in immune regulation and inflammatory signaling.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

TNF Receptor Associated Factor 5 (TRAF5)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 33.8 kDa Observed MW (SDS-PAGE): 35 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln181-Arg437 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TRAF5


dry ice

No


availability

Shipped within 5-7 working days.


alias

TRAF-5,TRAF5, MGC:39780, RNF84, TNF receptor associated factor 5


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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