Tissue Factor Pathway Inhibitor 2 (TFPI2) Antibody (FITC)
260€ (50 µl)
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935106861
info@markelab.com
name
Tissue Factor Pathway Inhibitor 2 (TFPI2) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx344662
Description
Tissue Factor Pathway Inhibitor 2 (TFPI2) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human TFPI2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tissue Factor Pathway Inhibitor 2 (TFPI2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48307 |
| Gene ID | 7980 |
| OMIM | 600033 |
| Alias | PP5,REF1,TFPI-2,Placental protein 5 |
| Background | Antibody anti-TFPI2 |
| Status | RUO |
Descripción
Tissue Factor Pathway Inhibitor 2 (TFPI2), another Kunitz-type inhibitor, is structurally similar to TFPI but exhibits distinct functions, primarily inhibiting plasmin and matrix metalloproteinases (MMPs). TFPI2 plays a critical role in modulating extracellular matrix degradation, cell migration, and angiogenesis, influencing processes like wound healing, tissue remodeling, and tumor progression. Unlike TFPI, TFPI2 is broadly expressed in various tissues and is frequently downregulated in cancers, where its loss contributes to tumor invasion, metastasis, and angiogenesis. Its epigenetic silencing through promoter hypermethylation is a hallmark in several malignancies, highlighting its potential as a tumor suppressor and biomarker for cancer diagnosis and prognosis.
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