Tissue Factor Pathway Inhibitor 2 (TFPI2) Antibody
195€ (20 µl)
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Name
Tissue Factor Pathway Inhibitor 2 (TFPI2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx006327
Tested Applications
ELISA, WB, IHC
Description
TFPI2 Antibody is a Rabbit Polyclonal Antibody against TFPI2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Tissue Factor Pathway Inhibitor 2 (TFPI2) Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-235 of human TFPI2. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 27 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48307 |
| Gene ID | 7980 |
| NCBI Accession | NP_006519.1 |
| Alias | PP5,REF1,TFPI-2,Placental protein 5 |
| Background | Antibody anti-TFPI2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Tissue Factor Pathway Inhibitor 2 (TFPI2), another Kunitz-type inhibitor, is structurally similar to TFPI but exhibits distinct functions, primarily inhibiting plasmin and matrix metalloproteinases (MMPs). TFPI2 plays a critical role in modulating extracellular matrix degradation, cell migration, and angiogenesis, influencing processes like wound healing, tissue remodeling, and tumor progression. Unlike TFPI, TFPI2 is broadly expressed in various tissues and is frequently downregulated in cancers, where its loss contributes to tumor invasion, metastasis, and angiogenesis. Its epigenetic silencing through promoter hypermethylation is a hallmark in several malignancies, highlighting its potential as a tumor suppressor and biomarker for cancer diagnosis and prognosis.
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