Human Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Human Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069324
tested applications
WB, SDS-PAGE
Description
Recombinant TFPI2 is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tissue Factor Pathway Inhibitor 2 (TFPI2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 26.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp23-Phe235 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48307 |
| Alias | PP5,REF1,TFPI-2,Placental protein 5 |
| Background | Protein TFPI2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Tissue Factor Pathway Inhibitor 2 (TFPI2), another Kunitz-type inhibitor, is structurally similar to TFPI but exhibits distinct functions, primarily inhibiting plasmin and matrix metalloproteinases (MMPs). TFPI2 plays a critical role in modulating extracellular matrix degradation, cell migration, and angiogenesis, influencing processes like wound healing, tissue remodeling, and tumor progression. Unlike TFPI, TFPI2 is broadly expressed in various tissues and is frequently downregulated in cancers, where its loss contributes to tumor invasion, metastasis, and angiogenesis. Its epigenetic silencing through promoter hypermethylation is a hallmark in several malignancies, highlighting its potential as a tumor suppressor and biomarker for cancer diagnosis and prognosis.
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