Tissue Factor Pathway Inhibitor 2 (TFPI2) Antibody (Biotin)

Este producto es parte de TFPI - Tissue factor pathway inhibitor
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260€ (50 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Tissue Factor Pathway Inhibitor 2 (TFPI2) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx344663
tested applications
ELISA

Description

Tissue Factor Pathway Inhibitor 2 (TFPI2) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human TFPI2.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Tissue Factor Pathway Inhibitor 2 (TFPI2)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G chromatography.
Size 1
50 µl
Size 2
100 µl
Size 3
200 µl
Size 4
1 ml
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P48307
Gene ID
7980
OMIM
600033
Alias
PP5,REF1,TFPI-2,Placental protein 5
Background
Antibody anti-TFPI2
Status
RUO

Descripción

Tissue Factor Pathway Inhibitor 2 (TFPI2), another Kunitz-type inhibitor, is structurally similar to TFPI but exhibits distinct functions, primarily inhibiting plasmin and matrix metalloproteinases (MMPs). TFPI2 plays a critical role in modulating extracellular matrix degradation, cell migration, and angiogenesis, influencing processes like wound healing, tissue remodeling, and tumor progression. Unlike TFPI, TFPI2 is broadly expressed in various tissues and is frequently downregulated in cancers, where its loss contributes to tumor invasion, metastasis, and angiogenesis. Its epigenetic silencing through promoter hypermethylation is a hallmark in several malignancies, highlighting its potential as a tumor suppressor and biomarker for cancer diagnosis and prognosis.

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