Telomeric Repeat-Binding Factor 1 (TERF1) Antibody
195€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Telomeric Repeat-Binding Factor 1 (TERF1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx000566
Tested Applications
ELISA, WB, IHC
Description
TERF1 Antibody is a Rabbit Polyclonal antibody against TERF1. Telomeres are nucleoprotein complexes located at chromosome ends that consist of tandem arrays of TTAGGG repeats bound to specific proteins. Telomeres protect chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. TERF1 (telomeric repeat-binding factor 1) binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. It's one component of the shelterin complex, which involved in the regulation of telomere length and protection.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Telomeric Repeat-Binding Factor 1 (TERF1) Immunogen: Recombinant protein corresponding to TERF1. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 50 kDa Observed MW: 50 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54274 |
| Gene ID | 7013 |
| NCBI Accession | NP_059523.2 |
| OMIM | 600951 |
| Alias | NIMA-interacting protein 2,PIN2,TRBF1,TRF,TRF1, t-TRF1, hTRF1-AS |
| Background | Antibody anti-TERF1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TERF1, also known as TRF1, is a key component of the shelterin complex that binds to double-stranded telomeric DNA, playing an essential role in telomere maintenance and genomic stability. TERF1 regulates telomere length by inhibiting telomerase activity, preventing inappropriate elongation of telomeres, and facilitating their replication and capping. It recruits other shelterin components and telomere-associated proteins to protect chromosome ends from being recognized as double-strand breaks, thereby preventing DNA damage responses and chromosome fusion. TERF1 is highly expressed in proliferative tissues, including stem cells and cancer cells, where telomere maintenance is critical for cellular longevity. Dysregulation of TERF1 contributes to telomere dysfunction, genomic instability, and diseases such as cancer and premature aging syndromes. Functional studies demonstrate that TERF1 deletion results in telomere uncapping, DNA damage accumulation, and activation of cell cycle arrest or apoptosis, underscoring its pivotal role in telomere integrity, chromosome stability, and cellular homeostasis.
Productos relacionados
Telomeric Repeat-Binding Factor 1 (TERF1) Antibody
TERF1 Antibody is a Rabbit Polyclonal antibody against TERF1. Telomeres are nucleoprotein complexes located at chromosom…
Ver producto
Human Telomeric Repeat-Binding Factor 1 (TERF1) Protein
Human Telomeric Repeat-Binding Factor 1 (TERF1) is a recombinant Human protein expressed in E. coli.…
Ver producto
Telomeric Repeat-Binding Factor 1 (TERF1) Antibody
Polyclonal Antibody to Telomeric Repeat-Binding Factor 1 (TERF1).…
Ver producto