TERF1 antibody
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Description
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | telomeric repeat binding factor (NIMA-interacting) 1 (TERF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 62 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P54274 |
| Gene ID | 7013 |
| Alias | NIMA-interacting protein 2,PIN2,TRBF1,TRF,TRF1, t-TRF1, hTRF1-AS |
| Background | Antibody anti-TERF1 |
| Status | RUO |
| Note | Mol. Weight 50 kDa |
Descripción
TERF1, also known as TRF1, is a key component of the shelterin complex that binds to double-stranded telomeric DNA, playing an essential role in telomere maintenance and genomic stability. TERF1 regulates telomere length by inhibiting telomerase activity, preventing inappropriate elongation of telomeres, and facilitating their replication and capping. It recruits other shelterin components and telomere-associated proteins to protect chromosome ends from being recognized as double-strand breaks, thereby preventing DNA damage responses and chromosome fusion. TERF1 is highly expressed in proliferative tissues, including stem cells and cancer cells, where telomere maintenance is critical for cellular longevity. Dysregulation of TERF1 contributes to telomere dysfunction, genomic instability, and diseases such as cancer and premature aging syndromes. Functional studies demonstrate that TERF1 deletion results in telomere uncapping, DNA damage accumulation, and activation of cell cycle arrest or apoptosis, underscoring its pivotal role in telomere integrity, chromosome stability, and cellular homeostasis.
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This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
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TERF1 Antibody is a Rabbit Polyclonal antibody against TERF1. Telomeres are nucleoprotein complexes located at chromosome ends that consist of tandem arrays of TTAGGG repeats bound to specific proteins. Telomeres protect chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. TERF1 (telomeric repeat-binding factor 1) binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. It's one component of the shelterin complex, which involved in the regulation of telomere length and protection.
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