Tachykinin Receptor 3 (TACR3) Antibody

Background

TACR3, also known as NK3R, is a G protein-coupled receptor activated by neurokinin B (NKB), a neuropeptide involved in regulating multiple physiological processes. TACR3 primarily couples to Gq proteins, stimulating phospholipase C (PLC), increasing intracellular calcium, and modulating cell signaling. It is predominantly expressed in the central nervous system (CNS), particularly in regions involved in regulating reproductive functions and controlling circadian rhythms. TACR3 plays a critical role in regulating the hypothalamic-pituitary-gonadal axis, influencing reproductive hormone release, and modulating sexual behavior. In addition, it is involved in controlling mood and anxiety by regulating neurogenic inflammation. Dysregulation of TACR3 signaling has been linked to conditions such as infertility, mood disorders, and certain cancers. Targeting TACR3 with antagonists offers potential therapeutic benefits in treating disorders related to reproductive function, anxiety, and neurogenic inflammation.