Tachykinin Receptor 3 (TACR3) Antibody
364€ (100 µg)
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935106861
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name
Tachykinin Receptor 3 (TACR3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx238472
tested applications
ELISA, WB, IHC
Description
TACR3 Antibody is a Rabbit Polyclonal against TACR3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tachykinin Receptor 3 (TACR3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29371 |
| Alias | TACR3,Neurokinin B receptor,neurokinin beta receptor,Nmkr,Tac3r,neuromedin K receptor,NK-3 receptor,SP-N receptor,HH11,NK-3R,NK3,NK3R,NKR,TAC3R,TAC3RL |
| Background | Antibody anti-TACR3 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
TACR3, also known as NK3R, is a G protein-coupled receptor activated by neurokinin B (NKB), a neuropeptide involved in regulating multiple physiological processes. TACR3 primarily couples to Gq proteins, stimulating phospholipase C (PLC), increasing intracellular calcium, and modulating cell signaling. It is predominantly expressed in the central nervous system (CNS), particularly in regions involved in regulating reproductive functions and controlling circadian rhythms. TACR3 plays a critical role in regulating the hypothalamic-pituitary-gonadal axis, influencing reproductive hormone release, and modulating sexual behavior. In addition, it is involved in controlling mood and anxiety by regulating neurogenic inflammation. Dysregulation of TACR3 signaling has been linked to conditions such as infertility, mood disorders, and certain cancers. Targeting TACR3 with antagonists offers potential therapeutic benefits in treating disorders related to reproductive function, anxiety, and neurogenic inflammation.
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