Synemin (SYNM) Antibody
364€ (100 µg)
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935106861
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name
Synemin (SYNM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx238440
tested applications
ELISA, WB, IHC, IF/ICC
Description
SYNM Antibody is a Rabbit Polyclonal against SYNM.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Synemin (SYNM) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15061 |
| Gene ID | 23336 |
| OMIM | 606087 |
| Alias | DMN,SYN,Desmuslin |
| Background | Antibody anti-SYNM |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Synemin (SYNM) is a protein that plays a key role in maintaining the structural integrity of cells, particularly in muscle and neuronal tissues SYNM is involved in linking the intermediate filaments of the cytoskeleton to other cell structures such as the plasma membrane and actin filaments, contributing to the maintenance of cell shape and mechanical strength In muscle cells, synemin is particularly important for the structural organization of the sarcomere, the basic contractile unit of muscle fibers It also plays a role in cellular signaling and the regulation of growth and differentiation Synemin has been linked to diseases involving defects in the cytoskeleton, such as muscular dystrophies, where its dysfunction leads to impaired cell stability and muscle weakness Additionally, synemin is involved in the regulation of synaptic function and neuronal signaling, highlighting its importance in both muscle and nerve cell health Understanding synemin’s role in cell function and its association with muscle and neurological diseases provides potential insights into therapies for these conditions
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