Syndecan 1 (SDC1) Protein

Background

Syndecan-1 (SDC1), a cell surface heparan sulfate proteoglycan, is encoded by the SDC1 gene and is part of the syndecan family, which includes four distinct proteoglycans (syndecans 1-4). These proteoglycans are integral to cell surface structure, functioning in cellular communication, adhesion, migration, and the regulation of growth factors. Syndecan-1 is expressed on various cell types, including epithelial cells, B cells, and plasma cells, where it plays crucial roles in cell-matrix interactions and intracellular signaling. Additionally, SDC1 is dynamically regulated in response to tissue injury and inflammation, underscoring its significance in wound healing, inflammation, and cancer progression.