Succinate receptor 1 (SUCNR1) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Succinate receptor 1 (SUCNR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx328072
tested applications
ELISA, WB, IF/ICC
Description
SUCNR1 Antibody is a Rabbit Polyclonal against SUCNR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Succinate receptor 1 (SUCNR1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BXA5 |
| Gene ID | 56670 |
| Alias | SUCNR1,succinate receptor 1,GPR91,P2Y purinoceptor 1,SUCNR1,G protein-coupled receptor 91 |
| Background | Antibody anti-SUCNR1 |
| Status | RUO |
Descripción
SUCNR1, also known as the succinate receptor, is a G protein-coupled receptor that is activated by succinate, an intermediate in the citric acid cycle and a key molecule in cellular metabolism. It primarily couples to Gi proteins, triggering intracellular signaling pathways that regulate vascular tone, inflammation, and metabolic processes. SUCNR1 is expressed in various tissues, including the kidney, vasculature, and immune cells. In the kidney, it plays a role in regulating blood pressure by modulating the renin-angiotensin system. In the vasculature, SUCNR1 is involved in regulating smooth muscle contraction and endothelial cell function, contributing to blood pressure homeostasis. Dysregulation of SUCNR1 has been linked to conditions such as hypertension, ischemia, and inflammation. SUCNR1 is also implicated in cancer progression, particularly in the context of tumor hypoxia. Targeting SUCNR1 with selective agonists or antagonists offers potential therapeutic strategies for managing metabolic diseases, cardiovascular disorders, and inflammation.
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