Striatin, Calmodulin Binding Protein (STRN) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
Striatin, Calmodulin Binding Protein (STRN) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx115867
tested applications
ELISA, WB
Description
Striatin, Calmodulin Binding Protein Antibody is a Rabbit Polyclonal antibody against Striatin, Calmodulin Binding Protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Striatin, Calmodulin Binding Protein (STRN) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43815 |
| Gene ID | 6801 |
| NCBI Accession | NP_003153.2, NM_003162.3 |
| OMIM | 614765 |
| Background | Antibody anti-STRN |
| Status | RUO |
Descripción
Striatin (STRN) is a scaffolding protein and a member of the striatin family, functioning as a critical component of the striatin-interacting phosphatase and kinase (STRIPAK) complex. STRN acts as an adaptor protein, facilitating protein-protein interactions and coordinating cellular signaling pathways, including protein phosphatase 2A (PP2A) activity and kinase signaling. It is highly expressed in the brain, heart, and endothelial tissues, where it participates in cellular processes such as vesicle trafficking, cytoskeletal organization, and signal transduction. STRN plays a significant role in neurodevelopment, neurotransmission, and endothelial cell function by regulating calcium-calmodulin-dependent pathways. Dysregulation of STRN is linked to neurological disorders, including neurodegenerative diseases, and cancers, where its involvement in PP2A activity affects tumor progression and cellular homeostasis. Knockdown studies reveal disrupted vesicular transport, impaired cell signaling, and defective cytoskeletal organization, underscoring its role in maintaining cell structure, signaling integrity, and physiological processes.
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