STRN antibody
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935106861
info@markelab.com
name
STRN antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08353
tested applications
ELISA, WB, IHC, IF
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | striatin, calmodulin binding protein (STRN) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 120 kDa, 80 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O43815 |
| Gene ID | 6801 |
| Alias | PPP2R6A,SG2NA,STRN1 |
| Background | Antibody anti-STRN |
| Status | RUO |
| Note | Mol. Weight 120 kDa, 80 kDa |
Striatin (STRN) is a scaffolding protein and a member of the striatin family, functioning as a critical component of the striatin-interacting phosphatase and kinase (STRIPAK) complex. STRN acts as an adaptor protein, facilitating protein-protein interactions and coordinating cellular signaling pathways, including protein phosphatase 2A (PP2A) activity and kinase signaling. It is highly expressed in the brain, heart, and endothelial tissues, where it participates in cellular processes such as vesicle trafficking, cytoskeletal organization, and signal transduction. STRN plays a significant role in neurodevelopment, neurotransmission, and endothelial cell function by regulating calcium-calmodulin-dependent pathways. Dysregulation of STRN is linked to neurological disorders, including neurodegenerative diseases, and cancers, where its involvement in PP2A activity affects tumor progression and cellular homeostasis. Knockdown studies reveal disrupted vesicular transport, impaired cell signaling, and defective cytoskeletal organization, underscoring its role in maintaining cell structure, signaling integrity, and physiological processes.
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