Striatin-3 (STRN3) Antibody
351€ (100 µg)
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935106861
info@markelab.com
name
Striatin-3 (STRN3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx375913
tested applications
ELISA, WB
Description
Striatin-3 (STRN3) Antibody is a Rabbit Polyclonal antibody against Striatin-3 (STRN3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Striatin-3 (STRN3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13033 |
| Gene ID | 29966 |
| Alias | PPP2R6B,S/G2NA,SG2NA,Cell cycle autoantigen SG2NA,S/G2 antigen |
| Background | Antibody anti-STRN3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Striatin-3 (STRN3), also known as SG2NA, is a member of the striatin family that functions as a scaffolding protein within the STRIPAK complex. STRN3 coordinates signaling events by interacting with PP2A, kinases, and other regulatory proteins to regulate cell signaling, cytoskeletal dynamics, and vesicular trafficking. It is expressed in various tissues, particularly in the brain, where it modulates calcium-calmodulin signaling pathways essential for neurodevelopment, synaptic plasticity, and neuronal communication. STRN3 plays additional roles in endothelial cell function, angiogenesis, and cell migration through its interactions with signaling proteins. Dysregulation of STRN3 has been implicated in cancers and neurological disorders, where altered PP2A activity and disrupted signaling pathways contribute to disease progression. Functional studies reveal that loss of STRN3 impairs cellular signaling, cytoskeletal reorganization, and vesicle transport, emphasizing its role in cellular communication, cytoskeletal integrity, and signaling homeostasis.
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