Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 (SART3) Antibody
312€ (60 µl)
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Name
Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 (SART3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx126511
Tested Applications
WB
Description
SART3 Antibody is a Rabbit Polyclonal against SART3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 (SART3) Immunogen: Recombinant fusion protein corresponding to human SART3 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 13 kDa/41 kDa/105 kDa/109 kDa Observed MW: 130 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15020 |
| Gene ID | 9733 |
| NCBI Accession | NP_055521.1 |
| OMIM | 611684 |
| Alias | DSAP1,P100,RP11-13G14,TIP110,p110,p110(nrb)Tat-interacting protein of 110 kDa |
| Background | Antibody anti-SART3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Spliceosome associated factor 3, U4/U6 recycling protein (SART3) is a multifunctional protein that plays a critical role in the recycling of U4/U6 snRNPs during spliceosome disassembly SART3 ensures the efficient reassembly of U4/U6 complexes, which are required for the next round of pre-mRNA splicing, maintaining the fidelity and efficiency of gene expression Beyond its role in splicing, SART3 interacts with RNA-binding proteins and participates in the regulation of alternative splicing, influencing proteomic diversity SART3 is also implicated in the regulation of telomerase activity and cellular senescence, linking its function to genome stability Dysregulation of SART3 has been associated with cancers and autoimmune diseases, where abnormal RNA splicing contributes to altered gene expression and disease progression Recent studies suggest that SART3 interacts with viral RNAs during infections, regulating host-pathogen interactions and immune responses Its role in RNA metabolism, spliceosome recycling, and genome integrity highlights its importance in maintaining cellular function and gene regulation pathways
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