Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 (SART3) Antibody
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Description
SART3 Antibody is a Rabbit Polyclonal against SART3.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 (SART3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15020 |
| Gene ID | 9733 |
| NCBI Accession | NP_055521.1 |
| OMIM | 611684 |
| Alias | DSAP1,P100,RP11-13G14,TIP110,p110,p110(nrb)Tat-interacting protein of 110 kDa |
| Background | Antibody anti-SART3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Spliceosome associated factor 3, U4/U6 recycling protein (SART3) is a multifunctional protein that plays a critical role in the recycling of U4/U6 snRNPs during spliceosome disassembly SART3 ensures the efficient reassembly of U4/U6 complexes, which are required for the next round of pre-mRNA splicing, maintaining the fidelity and efficiency of gene expression Beyond its role in splicing, SART3 interacts with RNA-binding proteins and participates in the regulation of alternative splicing, influencing proteomic diversity SART3 is also implicated in the regulation of telomerase activity and cellular senescence, linking its function to genome stability Dysregulation of SART3 has been associated with cancers and autoimmune diseases, where abnormal RNA splicing contributes to altered gene expression and disease progression Recent studies suggest that SART3 interacts with viral RNAs during infections, regulating host-pathogen interactions and immune responses Its role in RNA metabolism, spliceosome recycling, and genome integrity highlights its importance in maintaining cellular function and gene regulation pathways
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