Sphingosine 1-Phosphate Receptor 4 (S1PR4) Antibody
292.5€ (80 µl)
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Name
Sphingosine 1-Phosphate Receptor 4 (S1PR4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx032700
Tested Applications
ELISA, WB
Description
EDG6 is a member of the G protein-coupled receptors, as well as the EDG family of proteins. It participates in endothelial differentiation, and may regulate lymphocyte cell signaling. It is a member of the lysophospholipid/lysosphingolipid receptor family.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Sphingosine 1-Phosphate Receptor 4 (S1PR4) Immunogen: KLH-conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human EDG6. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 41.6 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95977 |
| Alias | S1PR4,EDG6,LPC1,S1P4,SLP4,endothelial differentiation G protein-coupled receptor 6 |
| Background | Antibody anti-S1PR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
S1PR4 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), primarily expressed in hematopoietic cells, including lymphocytes, dendritic cells, and natural killer (NK) cells. S1PR4 couples to Gi and G12/13 proteins, regulating pathways like PI3K/Akt and Rho/ROCK, which control cell migration, immune responses, and cytoskeletal reorganization. S1PR4 plays a critical role in immune cell trafficking, influencing lymphocyte egress from lymphoid tissues and modulating inflammatory responses. It is involved in regulating dendritic cell maturation and T-cell function, positioning it as a key player in adaptive immunity. Dysregulation of S1PR4 is associated with autoimmune diseases, inflammatory disorders, and hematological malignancies. In cancer, S1PR4 has been linked to tumor progression and immune evasion, particularly in leukemia and lymphoma. S1PR4 antagonists are being explored for therapeutic use in autoimmune diseases and cancers by modulating immune cell function and migration, highlighting its importance in immune regulation.
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