Sphingosine 1-Phosphate Receptor 3 (S1PR3) Antibody (Biotin)
169€ (20 µg)
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935106861
info@markelab.com
name
Sphingosine 1-Phosphate Receptor 3 (S1PR3) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx310563
tested applications
ELISA
Description
S1PR3 Antibody (Biotin) is a Rabbit Polyclonal against S1PR3 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sphingosine 1-Phosphate Receptor 3 (S1PR3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99500 |
| Gene ID | 1903 |
| OMIM | 601965 |
| Alias | S1PR3,C9orf108,C9orf47,EDG-3,EDG3,LPB3,S1P3,endothelial differentiation G protein-coupled receptor 3 |
| Background | Antibody anti-S1PR3 |
| Status | RUO |
Descripción
S1PR3 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), widely expressed in endothelial cells, smooth muscle cells, and immune cells. It couples to multiple G proteins (Gq, Gi, and G12/13), activating signaling pathways such as PI3K/Akt, MAPK, and Rho/ROCK. S1PR3 regulates vascular tone, endothelial barrier integrity, and smooth muscle contraction, contributing to blood flow regulation and vascular development. It also influences immune cell migration, inflammatory responses, and cardiac function. In the cardiovascular system, S1PR3 is essential for vasodilation and cardioprotection. Dysregulation of S1PR3 has been associated with chronic inflammation, cardiovascular diseases, and cancer progression. In tumor biology, S1PR3 promotes angiogenesis, metastasis, and immune cell infiltration into the tumor microenvironment. Therapeutically, targeting S1PR3 is being explored for its potential to regulate vascular inflammation, immune responses, and cancer metastasis, making it a promising target in inflammatory and cardiovascular diseases.
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