Sphingosine 1-Phosphate Receptor 3 (S1PR3) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Sphingosine 1-Phosphate Receptor 3 (S1PR3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx119625
tested applications
WB, IF/ICC
Description
EDG3 Antibody is a Rabbit Polyclonal antibody against EDG3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sphingosine 1-Phosphate Receptor 3 (S1PR3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99500 |
| Alias | S1PR3,C9orf108,C9orf47,EDG-3,EDG3,LPB3,S1P3,endothelial differentiation G protein-coupled receptor 3 |
| Background | Antibody anti-S1PR3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
S1PR3 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), widely expressed in endothelial cells, smooth muscle cells, and immune cells. It couples to multiple G proteins (Gq, Gi, and G12/13), activating signaling pathways such as PI3K/Akt, MAPK, and Rho/ROCK. S1PR3 regulates vascular tone, endothelial barrier integrity, and smooth muscle contraction, contributing to blood flow regulation and vascular development. It also influences immune cell migration, inflammatory responses, and cardiac function. In the cardiovascular system, S1PR3 is essential for vasodilation and cardioprotection. Dysregulation of S1PR3 has been associated with chronic inflammation, cardiovascular diseases, and cancer progression. In tumor biology, S1PR3 promotes angiogenesis, metastasis, and immune cell infiltration into the tumor microenvironment. Therapeutically, targeting S1PR3 is being explored for its potential to regulate vascular inflammation, immune responses, and cancer metastasis, making it a promising target in inflammatory and cardiovascular diseases.
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