Somatostatin Receptor 5 (SSTR5) Antibody

Background

SSTR5 is another G protein-coupled receptor in the somatostatin receptor family, activated by somatostatin. Like other somatostatin receptors, SSTR5 primarily couples to Gi proteins, reducing cAMP levels and inhibiting cell signaling. SSTR5 is expressed in various tissues, particularly in the brain, pancreas, and pituitary gland. In the pancreas, SSTR5 plays a role in regulating insulin and glucagon release, while in the brain, it modulates neurotransmission and hormone release. SSTR5 is also involved in regulating growth hormone secretion and influencing metabolic processes. Dysregulation of SSTR5 has been associated with various endocrine disorders, including pituitary adenomas and pancreatic tumors. Somatostatin analogs targeting SSTR5 are used clinically to treat conditions like acromegaly, neuroendocrine tumors, and other hormone-related disorders by reducing excessive hormone secretion.