SSTR5 antibody

Este producto es parte de SSTR - Somatostatin Receptor
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935106861
info@markelab.com
name
SSTR5 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08255
tested applications
ELISA, WB

Description

Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
somatostatin receptor 5 (SSTR5)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:2000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
50 kDa,65 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P35346
Gene ID
6755
Alias
SSTR5,SOMATO,SS-5-R,SST5
Background
Antibody anti-SSTR5
Status
RUO
Note
Mol. Weight 50 kDa, 65 kDa

Descripción

SSTR5 is another G protein-coupled receptor in the somatostatin receptor family, activated by somatostatin. Like other somatostatin receptors, SSTR5 primarily couples to Gi proteins, reducing cAMP levels and inhibiting cell signaling. SSTR5 is expressed in various tissues, particularly in the brain, pancreas, and pituitary gland. In the pancreas, SSTR5 plays a role in regulating insulin and glucagon release, while in the brain, it modulates neurotransmission and hormone release. SSTR5 is also involved in regulating growth hormone secretion and influencing metabolic processes. Dysregulation of SSTR5 has been associated with various endocrine disorders, including pituitary adenomas and pancreatic tumors. Somatostatin analogs targeting SSTR5 are used clinically to treat conditions like acromegaly, neuroendocrine tumors, and other hormone-related disorders by reducing excessive hormone secretion.

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