Somatostatin Receptor 1 (SSTR1) Antibody

Este producto es parte de SSTR - Somatostatin Receptor
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364€ (100 µg)

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935106861
info@markelab.com
name
Somatostatin Receptor 1 (SSTR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx238252
tested applications
ELISA, WB

Description

SSTR1 Antibody is a Rabbit Polyclonal against SSTR1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Somatostatin Receptor 1 (SSTR1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by immunogen affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P30872
Gene ID
6751
Alias
SSTR1,SRIF-2,SS1R,SRIF-2,SS-1-R,SS1-R,SST1
Background
Antibody anti-SSTR1
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

SSTR1 is a G protein-coupled receptor (GPCR) that binds somatostatin, a peptide hormone that inhibits the release of various other hormones, including growth hormone, insulin, and glucagon. SSTR1 is predominantly expressed in the brain, pancreas, and gastrointestinal tract. It primarily couples to Gi proteins, inhibiting adenylate cyclase activity and reducing cAMP levels, which leads to the suppression of hormone secretion and modulation of neurotransmitter release. In the central nervous system, SSTR1 regulates neurotransmission and has a role in inhibiting secretion of growth hormone from the pituitary. Dysregulation of SSTR1 signaling is implicated in disorders like acromegaly, diabetes, and certain neuroendocrine tumors, where excessive hormone secretion or abnormal growth occurs. SSTR1 agonists, such as octreotide, are used therapeutically to treat conditions such as acromegaly and neuroendocrine tumors by inhibiting growth hormone and other secretions.

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