SSTR1 antibody
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Description
Receptor for somatostatin with higher affinity for somatostatin-14 than-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | somatostatin receptor 1 (SSTR1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 53 kDa, 63 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P30872 |
| Gene ID | 6751 |
| Alias | SSTR1,SRIF-2,SS1R,SRIF-2,SS-1-R,SS1-R,SST1 |
| Background | Antibody anti-SSTR1 |
| Status | RUO |
| Note | Mol. Weight 53 kDa, 63 kDa |
Descripción
SSTR1 is a G protein-coupled receptor (GPCR) that binds somatostatin, a peptide hormone that inhibits the release of various other hormones, including growth hormone, insulin, and glucagon. SSTR1 is predominantly expressed in the brain, pancreas, and gastrointestinal tract. It primarily couples to Gi proteins, inhibiting adenylate cyclase activity and reducing cAMP levels, which leads to the suppression of hormone secretion and modulation of neurotransmitter release. In the central nervous system, SSTR1 regulates neurotransmission and has a role in inhibiting secretion of growth hormone from the pituitary. Dysregulation of SSTR1 signaling is implicated in disorders like acromegaly, diabetes, and certain neuroendocrine tumors, where excessive hormone secretion or abnormal growth occurs. SSTR1 agonists, such as octreotide, are used therapeutically to treat conditions such as acromegaly and neuroendocrine tumors by inhibiting growth hormone and other secretions.
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SSTR1 antibody
Receptor for somatostatin with higher affinity for somatostatin-14 than-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
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Somatostatin Receptor 1 (SSTR1) Antibody
SSTR1 Antibody is a Rabbit Polyclonal antibody against SSTR1. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28.
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