Soluble Leptin Receptor (sLEP-R) ELISA
560€ (96 det.)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Soluble Leptin Receptor (sLEP-R) ELISA
Category
ELISA Kits
Provider
Mediagnost
Reference
R07
Tested Applications
Elisa
Description
Quantitative measurement of soluble human leptin receptor (sLEP-R) in human serum or plasma for research purposes.
Descripción
Soluble Leptin Receptor (sLEP-R) ELISA permite la medición cuantitativa del receptor de leptina humano soluble (sLEP-R) en suero o plasma humano con fines de investigación.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Assay Data | Reference Material: Recombinant eukaryotically expressed soluble leptin receptor. Incubation Period: 5 h Calibrator: 8 individual standards, 0-30 ng/mL Controls: 2 serum controls, low and high level, respectively, lyophilized |
| Assay Type | Sandwich |
| Test Range | 0.0385-150 µg/L |
| Sensitivity | 0,0385 µg/L |
| Recommended Dilution | 1:5 |
| Origin | Antibody: Specific high-affinity antibodies |
| Size 1 | 96 det. |
| Tested Applications | Elisa |
| Sample Type | Serum / Plasma |
| Availability | 3-5 days. |
| Storage | Shelf life: between 1 and 2 years. Inquire about availability Store the kit at 2-8°C after receipt until its expiry date. |
| Alias | OBR, CD295, LEP-R |
| Background | Elisa Kits for: LEPR |
| Status | RUO |
| Note | Intra/Interassay Variance [%] < 10% |
Background
The adipokine leptin realizes signal transduction via four different leptin receptor (LEP-R) isoforms. The amount of functionally active LEP-R, however, is affected by constitutive shedding of the extracellular domain. The product of the cleavage process, the so-called soluble leptin receptor (sLEP-R, soluble Leptin receptor), is the main binding protein for leptin in human blood and modulates its bioavailability. Concentrations of sLEP-R are differentially regulated in metabolic disorders, such as type 1 diabetes mellitus or obesity and can therefore enhance or reduce leptin sensitivity. Lipotoxicity and apoptosis increase LEP-R cleavage via ADAM10-dependent mechanisms. In contrast, although increased sLEP-R concentrations seem directly to inhibit leptin effects, reduced amounts of sLEP-R may reflect decreased membrane expression of LEP-R. These findings, in part, explain alterations of leptin sensitivity that are associated with changes in serum sLEP-R concentrations seen in metabolic disorders.
Productos relacionados
Human Progranulin ELISA
The Mediagnost Progranulin ELISA is an assay with good reproducibility that detects progranulin and not granulins with h…
Ver producto Human Vaspin ELISA
Mediagnost ELISA for quantitative measurement of Vaspin in human serum is based on polyclonal rabbit antisera raised by …
Ver producto Functional Leptin Elisa
bioLEP ELISA a test for the measurement of biologically active leptinHere, the measurement is not based on two specific …
Ver producto