Human Progranulin ELISA

Product specifications

ELISA Kits

Human

Reference Material: recombinant progranulin
Incubation Period: 2h
Calibrator: recombinant progranulin
Controls: 2 controls lyophilised

Sandwich

0.018 – 103 µg/L

0.018 µg/L

1:41

Antibody: Mouse

96 det.

Elisa

EDTA / heparin / citrate plasma

3-5 days.

Shelf life: between 1 and 2 years
All reagents are stable until the indicated expiry, if stored unopened and protected from sunlight at 2 – 8°C

GEP,FTD2,GP88

Elisa Kits for: GRN

RUO

Intra/Interassay Variance [%]<10

Descripción

Human Progranulina Elisa Kit de Mediagnost es un ensayo con buena reproducibilidad que detecta progranulina y no granulinas con alta especificidad en muestras de suero y plasma humanos para uso en investigación.

Progranulin is also known as Granulin Epithelin Precursor, Proepithelin or Acrogranin. It is a 68.5 kDa protein, consisting of 593 amino acids (inclusive Signalpeptid), which appears in vivo in strongly glycosylated form and therefore has a size of approximately 90 kDa. Progranulin has seven conserved domains, which are separated by linker sequences. By means of proteolytic cleavage, catalyzed by serine proteases like e.g. elastase, 6-25 kDa large fragments result, that are called Granulines or Epithelines. Progranulin is expressed and secreted in particular in strongly proliferating tissues such as adenoid tissue, spleen, skin epithelium, gastrointestinal mucous membranes, haematopoietic cells and in tumor cells. Until now no specific receptors, which would obtain the effect of Progranulin or the Granulines are known . Progranulin seems to be a factor, which affects the wound healing positively. In case of skin lesions the expression is increased in ceratinocytes, in macrophages and in neutrophile cells. Progranulin affects the wound healing indirectly by activation of macrophages and stimulation of angiogenesis in the damaged tissue.

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