SIRT2-Specific Antibody
377€ (100 µg)
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Name
SIRT2-Specific Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx237880
Tested Applications
ELISA, WB, IHC, IP
Description
SIRT2-Specific Antibody is a Rabbit Polyclonal against SIRT2-Specific.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: SIRT2-Specific Immunogen: sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/20 - 1/200, IP: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 43 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8IXJ6 |
| Gene ID | 22933 |
| OMIM | 604480 |
| Alias | SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2 |
| Background | Antibody anti-SIRT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SIRT2 is another NAD+-dependent deacetylase that primarily localizes in the cytoplasm but can translocate to the nucleus under certain conditions to regulate cell cycle progression, metabolism, and oxidative stress SIRT2 deacetylates proteins involved in microtubule dynamics, such as α-tubulin, to maintain cellular morphology and mitotic integrity It also targets transcription factors including FOXO and p53, regulating cell proliferation, apoptosis, and stress resistance SIRT2 has a dual role in tumorigenesis, acting as a tumor suppressor by inhibiting cell proliferation and as a tumor promoter depending on the cellular context SIRT2 plays an essential role in metabolic regulation, particularly during caloric restriction, by modulating gluconeogenesis, insulin sensitivity, and lipid metabolism Dysregulation of SIRT2 has been linked to neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, where it influences protein aggregation and neuronal survival Pharmacological modulation of SIRT2 is under investigation for its therapeutic potential in cancer, metabolic disorders, and neurodegeneration
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