SIRT2-Specific Antibody

Este producto es parte de SIRT2 - Sirtuin 2
SIRT2-Specific Antibody

Pida mas información

935106861

info@markelab.com

Precio

364€ (100 µg)

Antibody anti-SIRT2

proveedor

Abbexa

reference

abx237880

Tested Applications

ELISA, WB, IHC, IP

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

SIRT2-Specific Antibody is a Rabbit Polyclonal against SIRT2-Specific.


Background

SIRT2 is another NAD+-dependent deacetylase that primarily localizes in the cytoplasm but can translocate to the nucleus under certain conditions to regulate cell cycle progression, metabolism, and oxidative stress SIRT2 deacetylates proteins involved in microtubule dynamics, such as α-tubulin, to maintain cellular morphology and mitotic integrity It also targets transcription factors including FOXO and p53, regulating cell proliferation, apoptosis, and stress resistance SIRT2 has a dual role in tumorigenesis, acting as a tumor suppressor by inhibiting cell proliferation and as a tumor promoter depending on the cellular context SIRT2 plays an essential role in metabolic regulation, particularly during caloric restriction, by modulating gluconeogenesis, insulin sensitivity, and lipid metabolism Dysregulation of SIRT2 has been linked to neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, where it influences protein aggregation and neuronal survival Pharmacological modulation of SIRT2 is under investigation for its therapeutic potential in cancer, metabolic disorders, and neurodegeneration

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

SIRT2-Specific


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC, IP


purity

≥ 95% (SDS-PAGE)


purification

Purified by immunogen affinity chromatography.


recommended dilution

WB: 1/500 - 1/1000, IHC: 1/20 - 1/200, IP: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.


size 1

100 µg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

SIRT2


dry ice

No


availability

Shipped within 5-12 working days.


alias

SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2


note

Concentration: 2 mg/ml - Validity: 12 months.


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