This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Sirtuins are a family of signaling proteins that play a crucial role in metabolic regulation. They are classified into two main types based on their enzymatic activities: mono-ADP-ribosyltransferases or deacylases. Sirtuins are involved in influencing a wide range of cellular processes, including aging, transcription, apoptosis, inflammation, and stress resistance. In humans, there are seven types of sirtuins known as SIRT1 through SIRT7. The first Sirtuin, Sir2, was initially discovered in yeast. SIRT2 participates in regulating microtubule acetylation, controlling myelination in the central and peripheral nervous systems, and influencing gluconeogenesis.
Las sirtuinas son una familia de proteínas de señalización que desempeñan un papel crucial en la regulación metabólica. Se clasifican en dos tipos principales según su actividad enzimática: mono-ADP-ribosiltransferasas o desacilasas. Las sirtuinas influyen en una amplia gama de procesos celulares, incluidos el envejecimiento, la transcripción, la apoptosis, la inflamación y la resistencia al estrés. En los seres humanos, existen siete tipos de sirtuinas conocidas como SIRT1 a SIRT7. La primera Sirtuin, Sir2, se descubrió inicialmente en levaduras. SIRT2 participa en la regulación de la acetilación de los microtúbulos, controla la mielinización en los sistemas nerviosos central y periférico e influye en la gluconeogénesis.
Primary Antibodies
polyclonal
human,rat
sirtuin (silent mating type information regulation 2 homolog) 2
Rabbit
IgG
Unconjugated
liquid
ELISA, WB, IHC, IF
Refer to Figures
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
SIRT2
SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2
This product is for research use only.
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