Human NAD-Dependent Protein Deacetylase Sirtuin-2 (SIRT2) ELISA Kit
715€ (96 tests)
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name
Human NAD-Dependent Protein Deacetylase Sirtuin-2 (SIRT2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx383209
tested applications
ELISA
Description
Human NAD-Dependent Protein Deacetylase Sirtuin-2 (SIRT2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human NAD-Dependent Protein Deacetylase Sirtuin-2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | NAD-Dependent Protein Deacetylase Sirtuin-2 (SIRT2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Sensitivity | 0.47 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8IXJ6 |
| Gene ID | 22933 |
| OMIM | 604480 |
| Alias | SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2 |
| Background | Elisa Kits for: SIRT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
SIRT2 is another NAD+-dependent deacetylase that primarily localizes in the cytoplasm but can translocate to the nucleus under certain conditions to regulate cell cycle progression, metabolism, and oxidative stress SIRT2 deacetylates proteins involved in microtubule dynamics, such as α-tubulin, to maintain cellular morphology and mitotic integrity It also targets transcription factors including FOXO and p53, regulating cell proliferation, apoptosis, and stress resistance SIRT2 has a dual role in tumorigenesis, acting as a tumor suppressor by inhibiting cell proliferation and as a tumor promoter depending on the cellular context SIRT2 plays an essential role in metabolic regulation, particularly during caloric restriction, by modulating gluconeogenesis, insulin sensitivity, and lipid metabolism Dysregulation of SIRT2 has been linked to neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, where it influences protein aggregation and neuronal survival Pharmacological modulation of SIRT2 is under investigation for its therapeutic potential in cancer, metabolic disorders, and neurodegeneration
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