Single Ig IL1 Related Receptor (SIGIRR) Antibody
312€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Single Ig IL1 Related Receptor (SIGIRR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx103370
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Single Ig IL1 Related Receptor (SIGIRR).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Single Ig IL1 Related Receptor (SIGIRR) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | SIGIRR, TIR8, IL-1R8,SIGIRR, TIR8, IL-1R8 |
| Background | Antibody anti-SIGIRR |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
SIGIRR, also known as IL1R8 or TIR8, is a member of the interleukin-1 receptor (IL-1R) family but functions as a negative regulator of Toll-like receptor (TLR) and IL-1R signaling pathways. SIGIRR contains a single immunoglobulin-like domain and a Toll/interleukin-1 receptor (TIR) domain, which mediate its inhibitory activity by preventing the recruitment of adaptor proteins like MyD88 and IRAK. It dampens the activation of downstream pathways, including NF-κB, MAPK, and AP-1, which are central to pro-inflammatory cytokine production. SIGIRR is highly expressed in epithelial cells, immune cells, and tissues like the intestine, lung, and kidney, where it helps maintain immune tolerance and protect against excessive inflammation. Dysregulation or deficiency of SIGIRR is linked to chronic inflammatory diseases, including inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), and autoimmune disorders, where unchecked signaling exacerbates tissue damage. Knockout studies reveal heightened inflammatory responses, increased cytokine production, and susceptibility to autoimmune and infectious diseases, emphasizing its role as a negative regulator in inflammation, immune homeostasis, and tissue protection.
Related Products
Human Single Ig IL1 Related Receptor (SIGIRR) Protein
Recombinant Single Ig IL1 Related Receptor (SIGIRR) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Ver ProductoRat Single Ig IL1 Related Receptor (SIGIRR) Protein
Recombinant Single Ig IL1 Related Receptor (SIGIRR) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Ver Producto
Mouse Single Ig IL1 Related Receptor (SIGIRR) Protein
Recombinant Single Ig IL1 Related Receptor (SIGIRR) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Ver Producto