Human Single Ig IL1 Related Receptor (SIGIRR) Protein
1391€ (1 mg)
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935106861
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name
Human Single Ig IL1 Related Receptor (SIGIRR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069096
tested applications
WB, SDS-PAGE
Description
Recombinant Single Ig IL1 Related Receptor (SIGIRR) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Single Ig IL1 Related Receptor (SIGIRR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 14.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-His118 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6IA17 |
| Alias | SIGIRR, TIR8, IL-1R8,SIGIRR, TIR8, IL-1R8 |
| Background | Protein SIGIRR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SIGIRR, also known as IL1R8 or TIR8, is a member of the interleukin-1 receptor (IL-1R) family but functions as a negative regulator of Toll-like receptor (TLR) and IL-1R signaling pathways. SIGIRR contains a single immunoglobulin-like domain and a Toll/interleukin-1 receptor (TIR) domain, which mediate its inhibitory activity by preventing the recruitment of adaptor proteins like MyD88 and IRAK. It dampens the activation of downstream pathways, including NF-κB, MAPK, and AP-1, which are central to pro-inflammatory cytokine production. SIGIRR is highly expressed in epithelial cells, immune cells, and tissues like the intestine, lung, and kidney, where it helps maintain immune tolerance and protect against excessive inflammation. Dysregulation or deficiency of SIGIRR is linked to chronic inflammatory diseases, including inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), and autoimmune disorders, where unchecked signaling exacerbates tissue damage. Knockout studies reveal heightened inflammatory responses, increased cytokine production, and susceptibility to autoimmune and infectious diseases, emphasizing its role as a negative regulator in inflammation, immune homeostasis, and tissue protection.
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