Family main features
Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR), also known as Toll/IL-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor (IL-1R) superfamily. SIGIRR is unique within this family due to its function as a negative regulator of Toll-like receptor (TLR) and IL-1R signaling pathways. This receptor plays a crucial role in controlling inflammation and maintaining immune homeostasis. SIGIRR is expressed in various tissues, including immune cells, epithelial cells, and fibroblasts. Its regulatory functions are essential for preventing excessive inflammatory responses that can lead to chronic inflammatory diseases.
SIGIRR is characterized by the following structural components:
SIGIRR is classified under the IL-1 receptor family and is often grouped with TLRs due to its involvement in regulating their signaling pathways. It does not have distinct subtypes but is often studied in the context of its interactions with various TLRs and IL-1Rs.
SIGIRR serves several critical roles in immune regulation:
Alterations in SIGIRR expression or function are associated with several pathological conditions:
Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR) is a critical negative regulator of TLR and IL-1R signaling pathways. Structurally, it features a unique single Ig-like extracellular domain, a transmembrane region, and an intracellular TIR domain tailored for inhibitory functions. SIGIRR is essential for controlling inflammation and maintaining immune homeostasis, protecting against chronic inflammatory diseases while balancing effective immune responses. Understanding SIGIRR's regulatory mechanisms offers valuable insights into potential therapeutic targets for treating inflammatory and autoimmune diseases, infections, and cancer.
Single Ig IL1 Related Receptor (SIGIRR)
SIGIRR,TIR8,IL-1R8,SIGIRR,TIR8,IL-1R8
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con SIGIRR - Single Ig IL1 Related Receptor
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Esta página contiene 12 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SIGIRR | abx385410 | Human Single Ig IL-1-related receptor (SIGIRR) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 743.75 | 96 tests | Q6IA17 | RUO |
Abbexa | SIGIRR | abx390572 | Mouse Single Ig IL-1-related receptor (SIGIRR) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 743.75 | 96 tests | Q9JLZ8 | RUO |
Abbexa | SIGIRR | abx391971 | Rat Single Ig IL-1-related receptor (SIGIRR) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q4V892 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SIGIRR | abx103368 | Single Ig IL1 Related Receptor (SIGIRR) Antibody | Human | Polyclonal | Rabbit | Single Ig IL1 Related Receptor (SIGIRR) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | SIGIRR | abx322637 | Single Ig IL-1-Related Receptor (SIGIRR) Antibody | Human | Polyclonal | Rabbit | Single Ig IL-1-Related Receptor (SIGIRR) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q6IA17 | RUO | |
Abbexa | SIGIRR | abx412062 | Single Ig IL-1-Related Receptor (SIGIRR) Antibody | Mouse | Polyclonal | Rabbit | Single Ig IL-1-Related Receptor (SIGIRR) | Unconjugated | WB, IHC | 475 | 100 µg | Q6IA17, Q9JLZ8 | RUO | |
Abbexa | SIGIRR | abx412063 | Single Ig IL-1-Related Receptor (SIGIRR) Antibody | Mouse | Polyclonal | Rabbit | Single Ig IL-1-Related Receptor (SIGIRR) | Unconjugated | WB, IHC | 275 | 50 µg | Q6IA17, Q9JLZ8 | RUO | |
Abbexa | SIGIRR | abx103369 | Single Ig IL1 Related Receptor (SIGIRR) Antibody | Mouse | Polyclonal | Rabbit | Single Ig IL1 Related Receptor (SIGIRR) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | SIGIRR | abx103370 | Single Ig IL1 Related Receptor (SIGIRR) Antibody | Rat | Polyclonal | Rabbit | Single Ig IL1 Related Receptor (SIGIRR) | Unconjugated | WB, IHC, IF/ICC | 300 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SIGIRR | abx069097 | Rat Single Ig IL1 Related Receptor (SIGIRR) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q4V892 | RUO |
Abbexa | SIGIRR | abx069096 | Human Single Ig IL1 Related Receptor (SIGIRR) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1337.5 | 1 mg | Q6IA17 | RUO |
Abbexa | SIGIRR | abx069098 | Mouse Single Ig IL1 Related Receptor (SIGIRR) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9JLZ8 | RUO |
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