Single Ig IL-1-Related Receptor (SIGIRR) Antibody

Este producto es parte de SIGIRR - Single Ig IL1 Related Receptor
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169€ (20 µl)

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935106861
info@markelab.com
name
Single Ig IL-1-Related Receptor (SIGIRR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx322637
tested applications
ELISA, WB, IHC

Description

SIGIRR Antibody is a Rabbit Polyclonal against SIGIRR.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetSingle Ig IL-1-Related Receptor (SIGIRR)
HostRabbit
ReactivityHuman, Mouse
Recommended DilutionWB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationAntigen Affinity Chromatography.
Size 120 µl
Size 250 µl
Size 3100 µl
Size 4200 µl
Size 51 ml
FormLiquid
Tested ApplicationsELISA, WB, IHC
BufferPBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDQ6IA17
Gene ID59307
NCBI AccessionNP_001128525.1, NM_001135053.1
OMIM605478
AliasSIGIRR, TIR8, IL-1R8,SIGIRR, TIR8, IL-1R8
BackgroundAntibody anti-SIGIRR
StatusRUO

Descripción

SIGIRR, also known as IL1R8 or TIR8, is a member of the interleukin-1 receptor (IL-1R) family but functions as a negative regulator of Toll-like receptor (TLR) and IL-1R signaling pathways. SIGIRR contains a single immunoglobulin-like domain and a Toll/interleukin-1 receptor (TIR) domain, which mediate its inhibitory activity by preventing the recruitment of adaptor proteins like MyD88 and IRAK. It dampens the activation of downstream pathways, including NF-κB, MAPK, and AP-1, which are central to pro-inflammatory cytokine production. SIGIRR is highly expressed in epithelial cells, immune cells, and tissues like the intestine, lung, and kidney, where it helps maintain immune tolerance and protect against excessive inflammation. Dysregulation or deficiency of SIGIRR is linked to chronic inflammatory diseases, including inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), and autoimmune disorders, where unchecked signaling exacerbates tissue damage. Knockout studies reveal heightened inflammatory responses, increased cytokine production, and susceptibility to autoimmune and infectious diseases, emphasizing its role as a negative regulator in inflammation, immune homeostasis, and tissue protection.
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