Signaling lymphocytic activation molecule (SLAMF1) Antibody

Descripción

Signaling lymphocytic activation molecule (SLAMF1) Antibody is a Rat Monoclonal antibody for the detection of CD150 (PE conjugated). CD150 is a 75-95 kDa member of the immunoglobulin superfamily, also known as SLAM (signalinglymphocyte activation molecule) orIPO-3. CD150, asingle chain type I transmembranemolecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells.The expression is upregulated upon activation. CD150 expression has been shown to bemaintained onTh1 but notTh2 clones.Tregulatory cells express a relatively high level of CD150.Antibodies against CD150 have been shown to augment IFN-g production byTh1 cells, especiallywhen co-stimulated through the TCR. CD150 associates with the src homology2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to beinvolved in signal transduction. In combination with CD48, CD150 is a useful marker forhematopoieticstem cell studies.