anti- SLAM/CD150 antibody
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | signaling lymphocytic activation molecule family member 1 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | WB: 1:200-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13291 |
| Alias | Signaling lymphocytic activation molecule,SLAM,CD150,CDw150,IPO-3,SLAM family member 1 |
| Background | Antibody anti-SLAMF1 |
| Status | RUO |
| Note | This product is for research use only. |
SLAMF1, also known as CD150, is a membrane glycoprotein and member of the signaling lymphocytic activation molecule (SLAM) family, which plays a critical role in modulating immune responses. It is encoded by the SLAMF1 gene and is primarily expressed on the surface of several immune cells, such as T cells, B cells, macrophages, and dendritic cells. SLAMF1 functions as a self-ligand, allowing it to engage in homophilic interactions that are essential for intercellular communication in immune responses. It influences a variety of immune processes, including cell activation, proliferation, cytokine production, and cytotoxic functions. This molecule plays a significant role in adaptive immunity by regulating immune cell interactions, positioning it as a critical factor in the immune response to pathogens and in autoimmune conditions.
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CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signalinglymphocyte activation molecule) orIPO-3. CD150, asingle chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained onTh1 but notTh2 clones.Tregulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-g production byTh1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoieticstem cell studies.
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