anti- CD150 antibody(PE conjugated)
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935106861
info@markelab.com
Precio
Precio a consultar
Antibody anti-SLAMF1
proveedor
FineTestreference
FNab09790Tested Applications
FCreactivity
mousestatus
RUOclonality
monoclonalDescripción
CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signalinglymphocyte activation molecule) orIPO-3. CD150, asingle chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained onTh1 but notTh2 clones.Tregulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-g production byTh1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoieticstem cell studies.
Background
SLAMF1, also known as CD150, is a membrane glycoprotein and member of the signaling lymphocytic activation molecule (SLAM) family, which plays a critical role in modulating immune responses. It is encoded by the SLAMF1 gene and is primarily expressed on the surface of several immune cells, such as T cells, B cells, macrophages, and dendritic cells. SLAMF1 functions as a self-ligand, allowing it to engage in homophilic interactions that are essential for intercellular communication in immune responses. It influences a variety of immune processes, including cell activation, proliferation, cytokine production, and cytotoxic functions. This molecule plays a significant role in adaptive immunity by regulating immune cell interactions, positioning it as a critical factor in the immune response to pathogens and in autoimmune conditions.
Características del producto
category
Primary Antibodies
clonality
monoclonal
reactivity
mouse
immunogen target
signaling lymphocytic activation molecule family member 1
host
Rat
isotype
IgG1
conjugation
Unconjugated
form
liquid
tested applications
FC
observerd MW
11kd
purity
≥95% as determined by SDS-PAGE
purification
Protein G purified
recommended dilution
1:10-1:50
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
SLAMF1
alias
Signaling lymphocytic activation molecule,SLAM,CD150,CDw150,IPO-3,SLAM family member 1
uniprot id
note
This product is for research use only.
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