Signal-Transducing Adaptor Protein 2 (STAP2) Antibody
292.5€ (80 µl)
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935106861
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name
Signal-Transducing Adaptor Protein 2 (STAP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026986
tested applications
ELISA, WB, IHC
Description
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signal-Transducing Adaptor Protein 2 (STAP2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UGK3 |
| Alias | STAP-2,Breast tumor kinase substrate,BRK substrate,STAP2,BKS |
| Background | Antibody anti-STAP2 |
| Status | RUO |
Descripción
Signal-transducing adaptor protein 2 (STAP2) is an adaptor protein that plays a significant role in intracellular signaling pathways by linking various receptors to downstream effectors, particularly within immune and inflammatory responses. It contains a PH domain, SH2 domain, and a proline-rich region, which facilitate its interaction with tyrosine-phosphorylated proteins and its localization to membrane-associated signaling complexes. STAP2 is implicated in the regulation of cytokine signaling pathways, such as those mediated by STAT3 and STAT5, influencing processes like cell survival, proliferation, and differentiation. It has been shown to interact with components of the T-cell receptor complex and Fc receptors, modulating immune responses and contributing to signal transduction in lymphocytes and macrophages. Dysregulation of STAP2 expression has been linked to pathological conditions, including autoimmune diseases, chronic inflammation, and cancer, where it may promote oncogenic signaling or alter immune surveillance. Additionally, STAP2 has been associated with metabolic regulation, as it can influence insulin signaling and adipocyte differentiation. Post-translational modifications of STAP2, such as phosphorylation and ubiquitination, regulate its activity and interaction networks, highlighting its role as a versatile adaptor in multiple signaling contexts.
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