Sialic Acid-Binding Ig-Like Lectin 9 (SIGLEC9) Antibody
195€ (20 µl)
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935106861
info@markelab.com
name
Sialic Acid-Binding Ig-Like Lectin 9 (SIGLEC9) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx003501
tested applications
ELISA, WB
Description
SIGLEC9 Antibody is a Rabbit Polyclonal antibody against SIGLEC9.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sialic Acid-Binding Ig-Like Lectin 9 (SIGLEC9) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y336 |
| Gene ID | 27180 |
| NCBI Accession | NP_001185487.1 |
| Alias | CD329,CDw329,FOAP-9,siglec-9,OBBP-LIKE |
| Background | Antibody anti-SIGLEC9 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
SIGLEC9 is widely expressed on neutrophils, monocytes, and subsets of T cells. It binds preferentially to α2-3-linked sialic acids on glycoproteins and glycolipids. SIGLEC9 plays a dual role in modulating immune responses by dampening excessive inflammation through its ITIM domains and enhancing the clearance of apoptotic cells by phagocytes. This protein is critical in host-pathogen interactions, as many pathogens exploit sialic acid-binding properties to evade immune detection. SIGLEC9 is being explored as a target in inflammatory diseases and cancer due to its role in modulating immune activation and resolution.
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