Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody
312€ (0.1 mg)
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Name
Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140625
Tested Applications
ELISA, FCM, IP
Description
Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody is a mouse monoclonal antibody against Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | A356 |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | ELISA, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q9NYZ4 |
| Gene ID | 27181 |
| Alias | SAF2,SIGLEC-8,SIGLEC8L,Sialoadhesin family member 2 |
| Background | Antibody anti-SIGLEC8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SIGLEC8 is an inhibitory receptor expressed mainly on eosinophils, mast cells, and basophils. It binds selectively to 6′-sulfated sialyl Lewis X and related glycan ligands, regulating inflammatory responses in allergic diseases. Activation of SIGLEC8 leads to eosinophil apoptosis and inhibition of mast cell degranulation, making it an attractive therapeutic target for asthma and eosinophilic disorders. Its function is mediated through ITIMs, which dampen cell activation pathways. SIGLEC8 is also implicated in maintaining immune homeostasis in tissues and resolving allergic inflammation.
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