Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody

Name: Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody
Brand: Abbexa
SKU: abx028703
Price: 281.25 EUR
Availability: OnlineOnly

Este producto es parte de SIGLEC - sialic acid binding Ig like lectin

Pida mas información

935106861

info@markelab.com

Precio

281.25€ (80 µl)

Antibody anti-SIGLEC8

proveedor

Abbexa

reference

abx028703

Tested Applications

ELISA, WB, IHC

reactivity

Human, Mouse

status

RUO

clonality

Polyclonal

Descripción

SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2, 3-linked sialic acid. and also binds to alpha2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.

Background

SIGLEC8 is an inhibitory receptor expressed mainly on eosinophils, mast cells, and basophils. It binds selectively to 6′-sulfated sialyl Lewis X and related glycan ligands, regulating inflammatory responses in allergic diseases. Activation of SIGLEC8 leads to eosinophil apoptosis and inhibition of mast cell degranulation, making it an attractive therapeutic target for asthma and eosinophilic disorders. Its function is mediated through ITIMs, which dampen cell activation pathways. SIGLEC8 is also implicated in maintaining immune homeostasis in tissues and resolving allergic inflammation.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC

purification

Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SIGLEC8

dry ice

availability

Shipped within 5-10 working days.

alias

SAF2,SIGLEC-8,SIGLEC8L,Sialoadhesin family member 2

uniprot id

https://www.uniprot.org/uniprotkb/Q9NYZ4

note

This product is for research use only.

Quizá le pueda interesar

Human SIGLEC8(Sialic Acid Binding Ig Like Lectin 8) ELISA Kit

proveedor

FineTest

reference

EH3783

reactivity

human

status

RUO

Precio a consultar