Name: Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody
Brand: Abbexa
SKU: abx128953
Price: 262.5 EUR
Availability: OnlineOnly

Background

SIGLEC8 is an inhibitory receptor expressed mainly on eosinophils, mast cells, and basophils. It binds selectively to 6′-sulfated sialyl Lewis X and related glycan ligands, regulating inflammatory responses in allergic diseases. Activation of SIGLEC8 leads to eosinophil apoptosis and inhibition of mast cell degranulation, making it an attractive therapeutic target for asthma and eosinophilic disorders. Its function is mediated through ITIMs, which dampen cell activation pathways. SIGLEC8 is also implicated in maintaining immune homeostasis in tissues and resolving allergic inflammation.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

WB, IHC, IF/ICC

purification

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

size 1

100 µl

size 2

200 µl

size 3

1 ml

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SIGLEC8

dry ice

availability

Shipped within 5-7 working days.

alias

SAF2,SIGLEC-8,SIGLEC8L,Sialoadhesin family member 2

uniprot id

https://www.uniprot.org/uniprotkb/Q9NYZ4

note

This product is for research use only.

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Human SIGLEC8(Sialic Acid Binding Ig Like Lectin 8) ELISA Kit

proveedor

FineTest

reference

EH3783

reactivity

human

status

RUO

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