Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) Antibody
169€ (20 µg)
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Name
Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx302741
Tested Applications
ELISA, WB, IHC
Description
SIGLEC6 Antibody is a Rabbit Polyclonal against SIGLEC6.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) Immunogen: Recombinant human Sialic acid-binding Ig-like lectin 6 protein (76-269AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43699 |
| Gene ID | 946 |
| NCBI Accession | NP_001171018.1, NM_001177547.2, NP_001171019.1, NM_001177548.2, NP_001171020.1, NM_001177549.2, NP_001236.4, NM_001245.6 |
| OMIM | 604405 |
| Alias | CD327,CD33L,OBBP1,CD33L1,CD33L2,CDW327,Obesity-binding protein 1,CD33 antigen-like 1 |
| Background | Antibody anti-SIGLEC6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SIGLEC6 is a member of the sialic acid-binding immunoglobulin-like lectin family, predominantly expressed on B cells, placental trophoblasts, and certain immune cells like mast cells. It binds to sialylated glycans, including α2,6-linked sialic acids, with high affinity for sialyl Tn antigen and leptin. SIGLEC6 functions as an inhibitory receptor, containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail that downregulates cellular activation pathways upon ligand binding. It plays a role in immune modulation, promoting tolerance during pregnancy by modulating trophoblast and maternal immune interactions. Dysregulation of SIGLEC6 has been implicated in gestational disorders like preeclampsia. Recent studies suggest its involvement in mast cell-mediated allergic responses and its potential as a therapeutic target in immune and metabolic disorders.
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