Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) Antibody
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Description
SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43699 |
| Alias | CD327,CD33L,OBBP1,CD33L1,CD33L2,CDW327,Obesity-binding protein 1,CD33 antigen-like 1 |
| Background | Antibody anti-SIGLEC6 |
| Status | RUO |
Descripción
SIGLEC6 is a member of the sialic acid-binding immunoglobulin-like lectin family, predominantly expressed on B cells, placental trophoblasts, and certain immune cells like mast cells. It binds to sialylated glycans, including α2,6-linked sialic acids, with high affinity for sialyl Tn antigen and leptin. SIGLEC6 functions as an inhibitory receptor, containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail that downregulates cellular activation pathways upon ligand binding. It plays a role in immune modulation, promoting tolerance during pregnancy by modulating trophoblast and maternal immune interactions. Dysregulation of SIGLEC6 has been implicated in gestational disorders like preeclampsia. Recent studies suggest its involvement in mast cell-mediated allergic responses and its potential as a therapeutic target in immune and metabolic disorders.
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