Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6) Antibody
637€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx115536
Tested Applications
ELISA, WB
Description
Sialic Acid Binding Ig-Like Lectin 6 Antibody is a Rabbit Polyclonal antibody against Sialic Acid Binding Ig-Like Lectin 6.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6) Immunogen: Human SIGLEC6. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43699 |
| Gene ID | 946 |
| NCBI Accession | NP_001171018.1, NM_001177547.2, NP_001171019.1, NM_001177548.2, NP_001171020.1, NM_001177549.2, NP_001236.4, NM_001245.6 |
| OMIM | 604405 |
| Alias | CD327,CD33L,OBBP1,CD33L1,CD33L2,CDW327,Obesity-binding protein 1,CD33 antigen-like 1 |
| Background | Antibody anti-SIGLEC6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SIGLEC6 is a member of the sialic acid-binding immunoglobulin-like lectin family, predominantly expressed on B cells, placental trophoblasts, and certain immune cells like mast cells. It binds to sialylated glycans, including α2,6-linked sialic acids, with high affinity for sialyl Tn antigen and leptin. SIGLEC6 functions as an inhibitory receptor, containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail that downregulates cellular activation pathways upon ligand binding. It plays a role in immune modulation, promoting tolerance during pregnancy by modulating trophoblast and maternal immune interactions. Dysregulation of SIGLEC6 has been implicated in gestational disorders like preeclampsia. Recent studies suggest its involvement in mast cell-mediated allergic responses and its potential as a therapeutic target in immune and metabolic disorders.
Productos relacionados
Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) Antibody
SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2, 6-lin…
Ver producto Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6) Antibody
Sialic Acid Binding Ig-Like Lectin 6 Antibody is a Rabbit Polyclonal antibody against Sialic Acid Binding Ig-Like Lectin…
Ver producto
Human Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) ELISA Kit
Human Sialic Acid Binding Ig Like Lectin 6 (SIGLEC6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement…
Ver producto