Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) Antibody (HRP)
169€ (20 µg)
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935106861
info@markelab.com
name
Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx308090
tested applications
ELISA
Description
SIGLEC15 Antibody (HRP) is a Rabbit Polyclonal against SIGLEC15 conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ZMC9 |
| Gene ID | 284266 |
| NCBI Accession | NP_998767.1 |
| Alias | CD33L3,HsT1361,SIGLEC-15,CD33 antigen-like 3 |
| Background | Antibody anti-SIGLEC15 |
| Status | RUO |
Descripción
SIGLEC15 is predominantly expressed on macrophages, dendritic cells, and osteoclasts. Unlike other Siglecs, SIGLEC15 shows specificity for modified sialic acids and is crucial for osteoclast development and bone resorption. It interacts with ligands on T cells to regulate immune responses, making it a potential target for cancer immunotherapy as it suppresses anti-tumor immunity. SIGLEC15 is highly expressed in the tumor microenvironment and has been associated with poor prognosis in certain cancers. Its roles extend to tissue remodeling and maintaining immune homeostasis in non-inflammatory conditions.
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