Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) Antibody

Este producto es parte de SIGLEC - sialic acid binding Ig like lectin
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026294
tested applications
ELISA, WB, IHC

Description

Binds sialylated glycoproteins.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetSialic Acid Binding Ig Like Lectin 15 (SIGLEC15)
HostRabbit
ReactivityHuman
Recommended DilutionWB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified through a protein A column, followed by peptide affinity purification.
Size 180 µl
Size 2400 µl
FormLiquid
Tested ApplicationsELISA, WB, IHC
BufferPBS containing 0.09% sodium azide.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDQ6ZMC9
AliasCD33L3,HsT1361,SIGLEC-15,CD33 antigen-like 3
BackgroundAntibody anti-SIGLEC15
StatusRUO

Descripción

SIGLEC15 is predominantly expressed on macrophages, dendritic cells, and osteoclasts. Unlike other Siglecs, SIGLEC15 shows specificity for modified sialic acids and is crucial for osteoclast development and bone resorption. It interacts with ligands on T cells to regulate immune responses, making it a potential target for cancer immunotherapy as it suppresses anti-tumor immunity. SIGLEC15 is highly expressed in the tumor microenvironment and has been associated with poor prognosis in certain cancers. Its roles extend to tissue remodeling and maintaining immune homeostasis in non-inflammatory conditions.
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