SH3 And PX Domains 2A (SH3PXD2A) Antibody
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Description
SH3PXD2A is required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns (3) P) and phosphatidylinositol 3, 4-biphosphate (PtdIns (3, 4) P2). In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH3 And PX Domains 2A (SH3PXD2A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5TCZ1 |
| Background | Antibody anti-SH3PXD2A |
| Status | RUO |
Descripción
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SH3PXD2A antibody
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases(ADAMs), NADPH oxidases(NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1-or NOX3-dependent reactive oxygen species(ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
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SH3 And PX Domains 2A (SH3PXD2A) Antibody
SH3PXD2A is required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns (3) P) and phosphatidylinositol 3, 4-biphosphate (PtdIns (3, 4) P2). In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
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