SH3PXD2A antibody
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Description
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases(ADAMs), NADPH oxidases(NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1-or NOX3-dependent reactive oxygen species(ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH3 and PX domains 2A (SH3PXD2A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 140 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q5TCZ1 |
| Gene ID | 9644 |
| Alias | SH3 and PX domain-containing protein 2A,Adapter protein TKS5,Five SH3 domain-containing protein,SH3 multiple domains protein 1,Tyrosine kinase substrate with five SH3 domains,SH3PXD2A,FISH,KIAA0418,SH3MD1,TKS5 |
| Background | Antibody anti-SH3PXD2A |
| Status | RUO |
| Note | Mol. Weight 140 kDa |
Descripción
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