SH2D4B Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
SH2D4B Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026496
tested applications
ELISA, WB, IHC, IF/ICC
Description
The function of this protein remains unknown.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2D4B |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5SQS7 |
| Alias | SH2D4B |
| Background | Antibody anti-SH2D4B |
| Status | RUO |
Descripción
SH2D4B is an SH2 domain-containing adaptor protein that functions as a modulator of cytokine and receptor tyrosine kinase signaling pathways. It negatively regulates signaling cascades such as JAK/STAT and PI3K/Akt by binding to phosphotyrosine residues on activated receptors or signaling intermediates, attenuating downstream signaling. SH2D4B is expressed in various tissues, including hematopoietic and epithelial cells, where it controls cellular proliferation, differentiation, and immune responses. It acts as a tumor suppressor by inhibiting excessive signaling that promotes cell survival and uncontrolled proliferation. Dysregulation or loss of SH2D4B expression is associated with cancer progression and immune dysfunction due to hyperactive cytokine signaling and impaired negative feedback regulation. Knockdown studies reveal increased cell proliferation, altered cytokine responses, and enhanced tumor growth, highlighting its role as a critical negative regulator of signal transduction and cellular homeostasis.
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